I've used 16.2 gr. WW296 (same as H110) in my two Pythons for with the 158 Sie. JHC for 38+ years. Accurate, not stressing my guns, killing deer out to 90 yds.( some really big WV bucks). Don't think any deer ram more than 10 yds.
Used the same load with 158 XTPs, but they didn't perform nearly as good as the Sierras.