I think that Jeff460 has never seen what a 300 gr or 325 gr A Frame can do on large dangerous game out of the 454 and 460....Cape Buff, Water Buff and even heard last week of a lady hunter that killed a hippo with a 325 gr A Frame out of a 454.....don't believe the fake news, it's obvious when folks have themselves never actually tried out certain Bullets...big bore bonded expanding bullets penetrate and reach and destroy the vitals on LARGE game....monometal bullets do what HC bullets do, but a lot better....if a non expanding bullet is desired.....

I don't know if it's big and bad, but this .44 WFN was recovered from a 491 lb bear.

It is a 320 grain 44 Magnum loaded by Reeds Ammunition to a claimed 1200 fps. I haven't chronographed them, but have no reason to doubt that number.
The bullet struck the treed bear in the cheek under the eye, then traveled up the spine, and stopped in the peak of the shoulders. Death was instant.
I don't mind that it expanded some.