I don't know if it's big and bad, but this .44 WFN was recovered from a 491 lb bear.
It is a 320 grain 44 Magnum loaded by Reeds Ammunition to a claimed 1200 fps. I haven't chronographed them, but have no reason to doubt that number.
The bullet struck the treed bear in the cheek under the eye, then traveled up the spine, and stopped in the peak of the shoulders. Death was instant.
I don't mind that it expanded some.