In 44mag I sight in my gun at ~78 yards. This puts it about +1.5" @ 50 yards and -1.5" @ 100 yards
Granted my normal hunting shot is ~50 yards but I prefer to set my gun up and leave the sights alone during the run-up and during the hunting season. I can't forsee myself taking a shot beyond 75 yards in the field but it is nice to have bullet drop to 100 in the event I need to make a followup shot.
I have an UltraDot on one pistol and a Leupold DeltaPoint on another.