I guess it's just my nature but I tend to like to stack the odds in my favor. Sometimes animals die easy, sometimes they take a whole lot of killing. Trouble is you don't know which type of animal it is until after you've taken the shot.
Which is why I've come to the conclusion one should carry the largest gun they can shoot well, and place the shots accordingly.
If all I had on me was a .327 and I had the right opportunity to take a deer would I? Absolutely! Would I choose a .327 with the intent to go out and hunt deer? Absolutely not.