I live in the Texas panhandle (open country) and therefore zero my revolvers a little further out than do some. All of mine are zeroed at 100 yds (with scopes & dot sights). I see open sights poorly enough that it is somewhat difficult for me to comfortably zero them at 100. Therefore, I shoot them in a little high at 50-60 yds. (Please note that I no longer hunt with open sights)
After getting the revolver shooting right @ 100 yds, I move to my steel "deer" at 137 yds. This is actually a metal cut-out of a bull elk but it is about 2/3 the size of a mature deer. A few shots on it will tell me if I am comfortable for that range.
When actually hunting deer sized animals or larger with a revolver, I try to limit myself to 125 yds or so. Opportunities at 50 yds or less are few and far between for me.
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It's more important where you hit 'em, than what you hit 'em with.