I chose the Ruger GP100 at 42 ounces as I liked the 5 1\2 half-lug barrel better than the Smith and Wesson 617 full-lug 4 or 6 inch barrel choices. Just my preference is all.
I did like the GP100 quite a bit. I got the SP101 because I liked the smaller frame for packing all the time, and it was a good deal as I got it used. I still may end up with a GP100 someday. .22LR revolvers are just fun to shoot.