Have used them for years in 44 mags, 445 Super Mags and 444 Marlin, handguns and long guns. Have taken antelope, deer and elk. Most, 99% are one shot kills. Angles from head-on, quartering, side, Texas heart shot. Distances from 20 yds. - to about 185 yds. Animals traveled from DRT to at most 50-60 yds.
Powder is generally an healthy charge of Accurate #9; although, have used WW296/H110 with good results. All used a firm, top down crimp.
I don't believe you will be disappointed.