For me a neck shot consists of shot placement at the base of the skull, top of the vertebrae juncture. Or, the base of the neck where the spine joins the shoulder juncture.
I have not done that with a revolver. But, several times with a scoped Specialty Pistol.
Provided a rest or stable platform, I have no issue with the shot within shooter/system capability.
My only issue with that shot...........there is no ballistic science to learn from it. Sever the spine, lights out instantly. You can do that with any chambering/bullet combination on whitetail. From a .22lr and 40gr LRN to a .500 S&W. There is no knowledge to be gained. It?s just skill and accuracy.
So, unless I?m specifically culling for meat, I try for body shots to learn more about a particular systems terminal ballistics.
"To Hell with efficiency, it's performance we want!" - Elmer Keith