I took a number of smallish, Texas bucks with just that combo. 125 XTP over a hot load of 2400. It worked great. On paper, it is certainly not ideal and I'd pick something else nowadays, but it was impressive performance nonetheless. If I found myself carrying that load and a shot presented itself within maybe 70 yards or so, I'd take it without concern. Again, these were not 250 lb Canadian border deer. Be reasonable and accurate, and that load can work wonderfully.
But for the grace of God, there, I go.