I shot a deer last year with my 6in GP-100 using the 158gr XTP-HP. Quartering towards me at about 21 yards, the bullet struck the point of the shoulder, passed through the heart/lungs, and lodged under the hide at the back of the ribs.
Deer ran a 94 yard half circle and died.
"To Hell with efficiency, it's performance we want!" - Elmer Keith